Cannon D J, Davison P F
Exp Aging Res. 1977 Mar;3(2):87-105. doi: 10.1080/03610737708257091.
The amount and type of borohydride-reducible crosslinks in collagen have been examined as a function of animal age. In a variety of bovine, canine and human tissues the level of redicible crosslinks decreases with time and the ratios of individual compounds change. There is both tissue and species specificity in the extent of these changes. A decrease in the level of reducible crosslinks correlates with the cessation of growth. Loss of reducible crosslinks does not imply a small total number of crosslinks since physical changes with age imply the opposite. We conclude that reducible crosslinks are converted to a stable nonreducible state and the persistence of low levels of reducible crosslinks may be indicative of a low level of turnover in the tissue. Changes in ratios of reducible crosslinks are of doubtful functioal significance and may simply reflect variation in post-translational modification of lysine residues.
已对胶原蛋白中硼氢化物可还原交联的数量和类型随动物年龄的变化进行了研究。在多种牛、犬和人类组织中，可还原交联的水平随时间下降，且各个化合物的比例发生变化。这些变化的程度存在组织和物种特异性。可还原交联水平的降低与生长停止相关。可还原交联的减少并不意味着交联总数少，因为随年龄的物理变化表明情况相反。我们得出结论，可还原交联转变为稳定的不可还原状态，可还原交联低水平的持续存在可能表明组织中的更新水平较低。可还原交联比例的变化其功能意义存疑，可能仅仅反映了赖氨酸残基翻译后修饰的差异。
