Oberley L W, Rogers K L, Schutt L, Oberley T D, Leuthauser S W, Sorenson J R
J Natl Cancer Inst. 1983 Nov;71(5):1089-94.
The effect of glutathione and a glutathione reductase inhibitor on the antitumor effect of Cu(II)(3,5-diisopropylsalicylate)2 (CuDIPS) was studied. CuDIPS is a low-molecular-weight copper coordination compound that exhibits superoxide dismutase-like activity. CuDIPS had antitumor activity against intraperitoneal Ehrlich ascites carcinoma in Swiss mice. A single ip injection of glutathione partially eliminated the antitumor effect of CuDIPS, whereas a single ip injection of 1,3-bis(2-chloroethyl)-1-nitrosourea enhanced the antitumor effect of CuDIPS. These results are consistent with the hypothesis that CuDIPS exerts part of its antitumor effect by producing H2O2.
研究了谷胱甘肽和谷胱甘肽还原酶抑制剂对Cu(II)(3,5-二异丙基水杨酸酯)2（CuDIPS）抗肿瘤作用的影响。CuDIPS是一种具有超氧化物歧化酶样活性的低分子量铜配位化合物。CuDIPS对瑞士小鼠腹腔内艾氏腹水癌具有抗肿瘤活性。单次腹腔注射谷胱甘肽部分消除了CuDIPS的抗肿瘤作用，而单次腹腔注射1,3-双(2-氯乙基)-1-亚硝基脲增强了CuDIPS的抗肿瘤作用。这些结果与CuDIPS通过产生H2O2发挥其部分抗肿瘤作用的假说一致。
