Azzarone B, Macieira-Coelho A, Curatolo L, Brouty-Boyé D, Varnier O, Donati M B, Morasca L
J Natl Cancer Inst. 1983 Nov;71(5):879-85.
Normal and established human epithelial cell lines obtained from the same organs were compared for their capacity to retract a fibrin clot. Fibrin clot retraction was maximal in normal epithelial cells, reduced in established nontumorigenic lines, and lost in tumorigenic cancer cell lines. Fibrin clot retraction efficiency seemed to be related to the degree of cellular spreading within the clot at the end of the test. Previous works and the present study suggest that fibrin clot retraction is correlated with some steps of cell transformation in vitro.
对从同一器官获取的正常和已建立的人类上皮细胞系进行比较，以研究它们回缩纤维蛋白凝块的能力。纤维蛋白凝块回缩在正常上皮细胞中最大，在已建立的非致瘤性细胞系中降低，而在致瘤性癌细胞系中则丧失。纤维蛋白凝块回缩效率似乎与测试结束时凝块内细胞铺展的程度有关。先前的研究和本研究表明，纤维蛋白凝块回缩与体外细胞转化的某些步骤相关。
