Miller C H, Mann S, Hamersley J, Glassy F J, O'Grady L F
West J Med. 1983 Oct;139(4):475-9.
Tumor cells from two patients with very different clinical diseases were evaluated using immunologic techniques. The first patient had a persistent T-cell lymphocytosis and other symptoms suggestive of T-cell malignancy. She also had an adnexal mass. Following surgical excision, the mass was identified as a benign teratoma that contained thymic tissue. The T-cell lymphocytosis subsided following removal of the mass. The second patient had leukemia, the cells of which were morphologically identified as myelomonocytic. Surface marker studies, however, showed the presence of monoclonal surface immunoglobulins. Enzymatic digestion of the cells showed that the antibodies were cytophilic and not produced by the tumor population. These studies emphasize the value of immunologic techniques in characterizing tumor cells.
运用免疫技术对两名患有截然不同临床疾病的患者的肿瘤细胞进行了评估。第一名患者患有持续性T细胞淋巴细胞增多症以及其他提示T细胞恶性肿瘤的症状。她还有一个附件肿物。手术切除后，该肿物被确定为含有胸腺组织的良性畸胎瘤。肿物切除后，T细胞淋巴细胞增多症消退。第二名患者患有白血病，其细胞在形态学上被鉴定为髓单核细胞。然而，表面标志物研究显示存在单克隆表面免疫球蛋白。对细胞进行酶消化后发现，这些抗体具有亲细胞性，并非由肿瘤细胞群体产生。这些研究强调了免疫技术在鉴定肿瘤细胞方面的价值。
