Aso K, Nakashima T, Miyachi Y, Nishikawa K, Ogawa A, Yafuso M, Kuno K
Jpn J Antibiot. 1983 Jun;36(6):1295-300.
Clinical trials were carried out with cefotetan (CTT) in pediatric infections. Results were as follows; The mean serum concentrations of CTT following intravenous injection of 20 mg/kg were 204, 97, 56, 15, 10 micrograms/ml at 15, 60, 120, 360, 480 minutes after injection. The serum half-life was 2.18 hours. 68.3% was excreted in urine within 8 hours after injection. In vitro, the antimicrobial activity of CTT was more active than CEZ and CMZ against E. coli, H. influenzae and K. pneumoniae. CTT was administered clinically to 22 pediatric patients with various infections; 9 pneumonias, 4 bronchopneumonias, 1 acute tonsillitis and 8 urinary tract infections. Overall efficacy rate was 95%. The favorable clinical response could be gained by the doses of 30 mg/kg with being given every 12 hours. Slight elevation of S-GOT and S-GPT with mild diarrhea was observed in 2 patients and eosinophilia in 1 patient. No other serious side effect was observed.
对头孢替坦（CTT）进行了儿科感染方面的临床试验。结果如下：静脉注射20mg/kg后，在注射后15、60、120、360、480分钟时CTT的平均血清浓度分别为204、97、56、15、10微克/毫升。血清半衰期为2.18小时。注射后8小时内68.3%经尿液排泄。体外实验中，CTT对大肠杆菌、流感嗜血杆菌和肺炎克雷伯菌的抗菌活性比头孢唑林（CEZ）和头孢孟多（CMZ）更强。临床上对22例患有各种感染的儿科患者使用了CTT；9例肺炎、4例支气管肺炎、1例急性扁桃体炎和8例尿路感染。总有效率为95%。每12小时给予30mg/kg的剂量可获得良好的临床反应。2例患者观察到谷草转氨酶（S-GOT）和谷丙转氨酶（S-GPT）轻度升高并伴有轻度腹泻，1例患者出现嗜酸性粒细胞增多。未观察到其他严重副作用。
