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血清素增强和去甲肾上腺素抑制药物诱导金黄仓鼠（Mesocricetus auratus）出现深度低温。

Profound hypothermia in golden hamsters (Mesocricetus auratus) induced by serotonergic potentiating and noradrenergic inhibiting drugs.

作者信息

Burns J T, Meier A H

出版信息

Experientia. 1978 May 15;34(5):607-8. doi: 10.1007/BF01936987.

DOI:10.1007/BF01936987
PMID:658238
Abstract

Profound hypothermia (6 degrees C) was induced in cold exposed golden hamsters (Mesocricetus auratus) by a combination of drugs that potentiate brain serotonergic activity (fluoxetine and pargyline) and inhibit noradrenergic activity (alpha-methyl-p-tyrosine). Individual drugs and combinations of 2 were ineffective.

摘要

通过联合使用增强脑血清素能活性的药物（氟西汀和帕吉林）以及抑制去甲肾上腺素能活性的药物（α-甲基-对-酪氨酸），使暴露于寒冷环境的金黄地鼠（Mesocricetus auratus）体温降至深度低温（6摄氏度）。单独使用这些药物或两两组合使用均无效。

相似文献

1
Profound hypothermia in golden hamsters (Mesocricetus auratus) induced by serotonergic potentiating and noradrenergic inhibiting drugs.血清素增强和去甲肾上腺素抑制药物诱导金黄仓鼠（Mesocricetus auratus）出现深度低温。
Experientia. 1978 May 15;34(5):607-8. doi: 10.1007/BF01936987.
2
Monoamines, estrogen and female sexual behavior in the golden hamster.金黄地鼠体内的单胺、雌激素与雌性性行为
Brain Res. 1978 Apr 7;144(1):109-21. doi: 10.1016/0006-8993(78)90438-9.
3
Nisoxetine antagonism of norepinephrine depletion in brain and heart after alpha-methyl-m-tyrosine administration.在给予α-甲基间酪氨酸后，尼索西汀对脑和心脏中去甲肾上腺素耗竭的拮抗作用。
Neuropharmacology. 1979 Oct;18(10):767-70. doi: 10.1016/0028-3908(79)90020-0.
4
The effect of a serotonin uptake inhibitor (Lilly 110140) on the sercretion of prolactin in the rat.
Life Sci. 1975 Oct 10;17(7):1141-4. doi: 10.1016/0024-3205(75)90336-7.
5
Monoamine oxidase. II. Time-dependent inhibition by propargylamines.单胺氧化酶。II. 炔丙胺的时间依赖性抑制作用。
Biochem Pharmacol. 1974 Feb 1;23(3):629-36. doi: 10.1016/0006-2952(74)90627-3.
6
Adrenocortical responses of rats to acute hypoxic and hypercapnic stresses after treatment with aminergic agents.用胺能药物治疗后大鼠对急性缺氧和高碳酸血症应激的肾上腺皮质反应。
Neuroendocrinology. 1976;20(2):182-92. doi: 10.1159/000122482.
7
Serotonergic stimulation of pituitary-adrenal activity in the mouse.小鼠垂体 - 肾上腺活动的5-羟色胺能刺激
Neuroendocrinology. 1978;26(5):312-24. doi: 10.1159/000122786.
8
Inhibition of drug metabolism by fluoxetine.氟西汀对药物代谢的抑制作用。
Res Commun Chem Pathol Pharmacol. 1976 Feb;13(2):353-6.
9
Effects of serotonergic drugs on methaqualone-induced hypothermia.
Res Commun Chem Pathol Pharmacol. 1977 Apr;16(4):629-36.
10
The effects of cold-stress. Hibernation, and prolonged inactivity on bone dynamics in the golden hamster, Mesocricetus auratus.冷应激、冬眠和长期不活动对金黄仓鼠（Mesocricetus auratus）骨骼动态的影响。
J Morphol. 1981 Jan;167(1):43-51. doi: 10.1002/jmor.1051670105.

本文引用的文献

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CHANGES IN TEMPERATURE PRODUCED BY MICRO-INJECTIONS OF AMINES INTO THE ANTERIOR HYPOTHALAMUS OF CATS.向猫的下丘脑前部微量注射胺类物质所产生的温度变化。
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A concept for a role of serotonin and norepinephrine as chemical mediators in the brain.
一种关于血清素和去甲肾上腺素作为大脑化学介质的作用的概念。
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Modification of the hypothermic action of morphine after depletion of brain serotonin and catecholamines.脑内5-羟色胺和儿茶酚胺耗竭后吗啡低温作用的改变
Life Sci I. 1971 Feb 1;10(3):175-80. doi: 10.1016/0024-3205(71)90091-9.
5
Blockade of arousal from hibernation by inhibition of norepinephrine synthesis in the golden hamster.通过抑制金黄仓鼠体内去甲肾上腺素的合成来阻断其从冬眠状态的觉醒。
Life Sci I. 1970 Oct 1;9(19):1117-25. doi: 10.1016/0024-3205(70)90143-8.
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The thermosensitivity of the hypothalamus and thermoregulation in mammals.哺乳动物下丘脑的温度敏感性与体温调节
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Further evidence for serotonin involvement in thermoregulation following morphine administration from studies with an inhibitor of serotonin uptake.使用5-羟色胺摄取抑制剂进行的研究为5-羟色胺参与吗啡给药后的体温调节提供了进一步的证据。
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Monoamines, pyrogens and cations: their actions on central control of bodytemperature.单胺类、致热原和阳离子：它们对体温中枢控制的作用。
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9
Is serotonin or are its metabolites responsible for induction of hypothermia?是血清素还是其代谢产物导致体温过低？
Experientia. 1976 Mar 15;32(3):334-6. doi: 10.1007/BF01940823.
10
[Effect of serotonin on body rewarming during awakening from hibernation].[血清素对冬眠苏醒过程中身体复温的影响]
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