温度变化对豚鼠心房抗毒蕈碱活性的影响。
Effect of variations in temperature on antimuscarinic activity in guinea-pig atria.
作者信息
Li C K, Mitchelson F
出版信息
Experientia. 1978 May 15;34(5):641-3. doi: 10.1007/BF01937009.
PMID:658257
Abstract
The characteristics of the antimuscarinic activity of homatropine, gallamine and stercuronium in guinea-pig atria remained constant over the temperature range 22--37 degrees C in that a linear Arunlakshana-Schild plot was obtained with homatropine and nonlinear plots occurred with gallamine or stercuronium. A trend towards higher dose-ratios with reduction in temperature was only significant for gallamine.
摘要
在22至37摄氏度的温度范围内，后马托品、加拉明和司可罗宁在豚鼠心房中的抗毒蕈碱活性特征保持不变，即后马托品得到线性阿伦拉克沙纳-席尔德图，而加拉明或司可罗宁得到非线性图。仅加拉明呈现出随着温度降低剂量比升高的趋势，且这种趋势具有显著性。
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