Thureson-Klein A, Wang-Yang J, Ho I K
Experientia. 1978 Jun 15;34(6):773-4. doi: 10.1007/BF01947319.
After morphine injection lipid accumulation in mouse hepatocytes begins within 2 h and continues for 24 h when most hepatocytes are filled with lipid droplets. In spite of morphine maintenance the liver recovers as the accumulated lipids are coupled with protein and subsequently transported and released into the perisinusoidal space of Disse.
注射吗啡后,小鼠肝细胞内的脂质积累在2小时内开始,并持续24小时,此时大多数肝细胞充满脂滴。尽管持续给予吗啡,但随着积累的脂质与蛋白质结合,随后被转运并释放到狄氏间隙,肝脏仍会恢复。