Schramm W, Friesen H G, Robertson H A, McCracken J A
J Reprod Fertil. 1984 Mar;70(2):557-65. doi: 10.1530/jrf.0.0700557.
The ability of ovine placental lactogen (oPL) to stimulate progesterone secretion by the ovary as well as its ability to protect the corpus luteum against the luteolytic action of PGF-2 alpha was investigated. When oPL was infused alone into the ovary for 2 h on Day 12 of an induced cycle at rates of 0.6, 6.0, 30.0 or 60.0 micrograms/h there was no significant increase in progesterone secretion by the autotransplanted ovary in 7 sheep. An extension of the infusion of oPL did not prevent luteal regression during the administration of PGF-2 alpha given either continuously (10 micrograms/h for 6 h, 5 sheep) or as 5 pulses each lasting 1 h and of increasing concentration in 25 h (2 sheep). We conclude that oPL does not (a) stimulate progesterone secretion when infused directly into the arterial supply of the ovary or (b) have any direct protective effect against the luteolytic action of PGF-2 alpha on the ovine CL.
研究了绵羊胎盘催乳素（oPL）刺激卵巢分泌孕酮的能力及其保护黄体免受前列腺素F-2α（PGF-2α）溶黄体作用的能力。在诱导周期的第12天，以0.6、6.0、30.0或60.0微克/小时的速率将oPL单独注入7只绵羊的卵巢中2小时，自体移植卵巢的孕酮分泌没有显著增加。延长oPL的输注时间并不能阻止在持续给予PGF-2α（10微克/小时，持续6小时，5只绵羊）或以5个脉冲形式给予PGF-2α（每个脉冲持续1小时，在25小时内浓度逐渐增加，2只绵羊）期间的黄体退化。我们得出结论，当直接注入卵巢的动脉供应时，oPL不会（a）刺激孕酮分泌，或（b）对PGF-2α对绵羊黄体的溶黄体作用具有任何直接保护作用。
