Dearth J, Osborn R, Wilson E, Kelly D, Mantle J, Rogers E, Malluh A, Crist W
Med Pediatr Oncol. 1984;12(1):54-8. doi: 10.1002/mpo.2950120113.
Although anthracycline antibiotics are among the most useful chemotherapy agents, the risk of producing cardiomyopathy and the absence of a reliable noninvasive technique to predict subclinical cardiomyopathy remain a major problem. We retrospectively reviewed our experience with anthracyclines over a 5-year period. Cardiomyopathy developed in 6 of 112 patients (5.3%) treated with anthracyclines and was fatal in 5 of the 6 patients. Our incidence and mortality rates are higher than those previously reported.
尽管蒽环类抗生素是最有用的化疗药物之一，但产生心肌病的风险以及缺乏可靠的非侵入性技术来预测亚临床心肌病仍然是一个主要问题。我们回顾性地分析了我们在5年期间使用蒽环类药物的经验。在112例接受蒽环类药物治疗的患者中，有6例（5.3%）发生了心肌病，其中5例死亡。我们的发病率和死亡率高于先前报道的。
