Chilcote R R, Coccia P, Sather H N, Robison L L, Baehner R L, Nesbit M E, Hammond D
Med Pediatr Oncol. 1984;12(1):9-16. doi: 10.1002/mpo.2950120105.
Patients with acute lymphoblastic leukemia who have a mediastinal mass at the time of diagnosis are said to have a poor prognosis. However, many factors which may not be independent contribute to the success of treatment. We compared the disease characteristics and results of therapy in children having large mediastinal masses and lymphoblastic leukemia without mediastinal mass. Patients with a mediastinal mass had less evidence of marrow failure but were burdened with considerably more leukemic cells as measured by peripheral blood white count and extent of lymphadenopathy. Since the presence of mediastinal mass was strongly associated with these and other poor prognostic characteristics, we used multivariate techniques to determine which characteristics were independently associated with an increased risk for relapse. White count, extent of lymphadenopathy, age, and sex were significant predictors of early relapse, but when controlled for these variables the presence of a mass did not predict prognosis.
诊断时患有纵隔肿块的急性淋巴细胞白血病患者据说预后较差。然而，许多可能并非独立的因素有助于治疗的成功。我们比较了患有大纵隔肿块的儿童和无纵隔肿块的淋巴细胞白血病儿童的疾病特征和治疗结果。有纵隔肿块的患者骨髓衰竭迹象较少，但根据外周血白细胞计数和淋巴结病范围测量，其白血病细胞负担要大得多。由于纵隔肿块的存在与这些及其他不良预后特征密切相关，我们使用多变量技术来确定哪些特征与复发风险增加独立相关。白细胞计数、淋巴结病范围、年龄和性别是早期复发的重要预测因素，但在控制这些变量后，肿块的存在并不能预测预后。
