Dubileĭ P V
Farmakol Toksikol. 1978 Mar-Apr;41(2):164-7.
Tests on isolated perfused lungs of albino rats were conducted to study the effect of iprazide (5.10(4) M) on inactivation of serotonin (5-OT) by the pulmonary tissue. Iprazide does not noticeably inhibit the inactivation of 5-OT, but it greatly reduces the activity of pulmonary monoaminoxidase, the consequence of which is accumulation of appreciable amount of 5-OT in the lungs. The 5-OT protected against destruction amasses in the cytoplasm and is not bound with cellular organoids.
对白化病大鼠的离体灌注肺进行了试验，以研究伊普拉嗪（5×10⁻⁴ M）对肺组织使血清素（5-羟色胺，5-OT）失活的影响。伊普拉嗪不会显著抑制5-OT的失活，但它会大大降低肺单胺氧化酶的活性，其结果是肺中积累了相当数量的5-OT。受到保护而免遭破坏的5-OT积聚在细胞质中，且不与细胞器结合。
