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[类黄酮的合成代谢作用]

[Anabolic action of flavonoids].

作者信息

Sokolova V E, Vasil'chenko E A, Izmaĭlova I K

出版信息

Farmakol Toksikol. 1978 May-Jun;41(3):323-7.

PMID:658381
Abstract

Flavonoids robinin and hyperin lengthen the average survival time of albino mice subjected to bilateral nephrectomy when introduced to the animals intraperitoneally in different doses. The effect of the study substances is inferior to that of dianabol with EU20 of robinin amounting to 82 mg/kg, of hyperin--88 mg/kg and that of dianabol--4.2 mg/kg. The methioned agents and also flavonoid lespedine enlarge the body mass and that of the musculus levator ani in growing castrated rats, when introduced by the intra peritoneal route in a dose of 100 mg/kg. Flavonoid robinin produces the greatest anabolic effect in tests set up both on mice and rats. The data obtained allow the spectrum of the biological action of flavonoids to be extended to some of their positive influence on the catabolic-anabolic processes.

摘要

黄酮类化合物刺槐苷和金丝桃苷以不同剂量经腹腔注射给白化小鼠后,可延长双侧肾切除小鼠的平均存活时间。研究物质的效果低于大力补,刺槐苷的等效剂量为82毫克/千克,金丝桃苷为88毫克/千克,大力补为4.2毫克/千克。甲硫氨酸制剂以及黄酮类化合物胡枝子苷以100毫克/千克的剂量经腹腔注射给生长中的去势大鼠后,可增加其体重及提肛肌的重量。黄酮类化合物刺槐苷在对小鼠和大鼠进行的试验中产生的合成代谢作用最强。所得数据使黄酮类化合物的生物作用谱得以扩展,涵盖其对分解代谢-合成代谢过程的一些积极影响。

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