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[甲状腺降钙素对实验性骨质疏松症矿物质代谢的影响]

[Effect of thyrocalcitonin on mineral metabolism in experimental osteoporosis].

作者信息

Golinskaia M S

出版信息

Farmakol Toksikol. 1978 May-Jun;41(3):334-8.

PMID:658384
Abstract

By the method of radioactive indication of ashed specimens of the femur, tibia, jaw bones and molars on a model of experimental osteoporosis in rats it is shown that the degree of mineralization of calcified tissues increases under the effect of thyrocalcitonin (TCT). The hypermineralization of jaw bones and, especially, of molars was attended by a lower 45Ca inclusion in these tissues. The structure of the adrenal cortex, kidneys, pancreas and thyroid returned back to normal under the effect of TCT and with carbohydrate rich nutrition, this occurring against the background of a high 45Ca concentration in these organs.

摘要

通过对大鼠实验性骨质疏松模型的股骨、胫骨、颌骨和磨牙的灰化标本进行放射性示踪法表明,在甲状腺降钙素(TCT)的作用下,钙化组织的矿化程度增加。颌骨尤其是磨牙的过度矿化伴随着这些组织中较低的45Ca掺入。在TCT的作用下,肾上腺皮质、肾脏、胰腺和甲状腺的结构恢复正常,并且在富含碳水化合物的营养条件下,这种情况发生在这些器官中高45Ca浓度的背景下。

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