[利血平对ACNU耐药C6胶质瘤生长抑制作用的增强效应]
[Enhanced effect of reserpine on growth-inhibitory action of ACNU on ACNU resistance C6 glioma].
作者信息
Yoshida T, Shimizu K, Ushio Y, Hayakawa T, Mogami H, Sakamoto Y
出版信息
Gan To Kagaku Ryoho. 1984 Mar;11(3):464-6.
PMID:6584086
Abstract
Reserpine was found to enhance the effect of ACNU on ACNU-resistant C6 glioma (C6/ACNU). When reserpine was added to the culture medium at the concentration of 10 microM, the IC50 of ACNU for C6/ACNU was decreased to the level of that for C6. Intracellular uptake of ACNU increased in both resistant and sensitive cells when 10 microM reserpine was added to the culture medium. This phenomenon is more remarkable in C6/ACNU than in C6.
摘要
发现利血平可增强阿糖胞苷对阿糖胞苷耐药的C6胶质瘤（C6/ACNU）的作用。当以10微摩尔/升的浓度将利血平添加到培养基中时，阿糖胞苷对C6/ACNU的IC50降低至其对C6的水平。当向培养基中添加10微摩尔/升利血平时，耐药细胞和敏感细胞内阿糖胞苷的摄取均增加。这种现象在C6/ACNU中比在C6中更显著。
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