Zhulova N A, Palyga G F, Maksimenko A A, Vacek A
Radiobiologiia. 1984 Jan-Feb;24(1):94-6.
In experiments on (CBA X C57Bl)F1 mice irradiated with doses of 8-12 Gy a study was made of the effect of a mixture of polyI-polyC (2.5 mg/kg, 2 days before irradiation) and mexamine (30 mg/kg, 5 min before irradiation) on the survival rate of animals and the times of their death. It was shown that polyI-polyC potentiates the protective effect of mexamine not increasing its toxicity. The protective agents used in a combination decrease the "intestinal" death of irradiated animals while used separately fail to produce this effect.
在用8 - 12戈瑞剂量照射的(CBA×C57Bl)F1小鼠实验中,研究了聚肌胞苷酸(聚I-聚C,2.5毫克/千克,照射前2天)和吗啉胍(30毫克/千克,照射前5分钟)混合物对动物存活率及其死亡时间的影响。结果表明,聚I-聚C增强了吗啉胍的保护作用,而未增加其毒性。联合使用的保护剂可降低受照射动物的“肠道”死亡,而单独使用则无此效果。