Willner P, Towell A, Montgomery T
Eur J Pharmacol. 1984 Mar 2;98(3-4):397-406. doi: 10.1016/0014-2999(84)90288-7.
Amphetamine-induced anorexia and stereotyped behaviour were studied in rats, following pretreatment with the antidepressants DMI, inprindole and mianserin. A complex drug-dependent and dose-dependent pattern of results was obtained. Acute pretreatment with DMI and iprindole enhanced amphetamine anorexia and stereotypy; at high doses only, the enhancement of anorexia disappeared during chronic treatment. Mianserin had no effects acutely, but chronic treatment with high doses attenuated anorexia and enhanced stereotypy. High doses of all three drugs attenuated anorexia and enhanced stereotypy during withdrawal. The most parsimonious account of these results is that the acute affects of DMI and iprindole are artefactual, and that chronic administration of all three antidepressants increased dopaminergic function and decreased beta-adrenergic function.
在用抗抑郁药去甲丙咪嗪、吲哚洛尔和米安色林预处理大鼠后，研究了苯丙胺引起的厌食和刻板行为。得到了一种复杂的药物依赖性和剂量依赖性的结果模式。去甲丙咪嗪和吲哚洛尔的急性预处理增强了苯丙胺引起的厌食和刻板行为；仅在高剂量时，厌食的增强在慢性治疗期间消失。米安色林急性时无作用，但高剂量的慢性治疗减弱了厌食并增强了刻板行为。在撤药期间，所有三种药物的高剂量都减弱了厌食并增强了刻板行为。对这些结果最简洁的解释是，去甲丙咪嗪和吲哚洛尔的急性作用是人为造成的，并且所有三种抗抑郁药的慢性给药增加了多巴胺能功能并降低了β-肾上腺素能功能。
