Fagerström P O
Eur J Respir Dis Suppl. 1984;134:101-10.
The basal model-independent pharmacokinetic parameters body clearance (CL), renal clearance (CLR), mean residence time (MRT), and volume of distribution in steady state (Vss) were calculated from concentrations of terbutaline in plasma and amounts in urine after intravenous administration of the drug in 19 healthy men. The data used were from three separate studies. Measurements up to 12 h gave estimated values for CL from 136 mL/min to 340 mL/min, for CLR from 82 mL/min to 192 mL/min, for MRT from 1.5 h to 5.6 h, and for Vss from 24 L to 73 L. In 6 subjects, there were measurements for longer than 24 h that could be used to calculate the parameters. Body clearance was now found to vary between 165 and 270 mL/min. MRT between 7.3 and 11.7 h, and Vss between 83 and 140 L. The evaluations indicate that CL will be overestimated and MRT and Vss underestimated from data only up to 12 h.
在19名健康男性静脉注射特布他林后，根据血浆中特布他林的浓度和尿液中的含量，计算了与模型无关的基础药代动力学参数，即机体清除率（CL）、肾清除率（CLR）、平均驻留时间（MRT）和稳态分布容积（Vss）。所使用的数据来自三项独立研究。长达12小时的测量结果显示，CL的估计值为136 mL/分钟至340 mL/分钟，CLR为82 mL/分钟至192 mL/分钟，MRT为1.5小时至5.6小时，Vss为24 L至73 L。在6名受试者中，有超过24小时的测量数据可用于计算这些参数。现在发现机体清除率在165至270 mL/分钟之间变化。MRT在7.3至11.7小时之间，Vss在83至140 L之间。评估表明，仅根据长达12小时的数据，CL将被高估，而MRT和Vss将被低估。
