Weisburger E K, Murthy A S, Lilja H S, Lamb J C
J Natl Cancer Inst. 1984 Jun;72(6):1457-63.
Feeding 4,4'-methylenebis(N,N-dimethyl)benzenamine [CAS: 101-61-1; 4,4'-methylenebis(N,N-dimethylaniline)] to inbred F344 rats increased the incidence of thyroid lesions (hyperplasia, adenomas, and carcinomas) in both sexes, especially in the female rats. 4,4'- Oxydianiline (CAS: 101-80-4) in the diet increased adenomas and carcinomas in the thyroid gland and neoplastic nodules and carcinomas in the liver of male and female F344 rats. In addition to increasing thyroid adenomas in females and hepatocellular adenomas or carcinomas in male and female B6C3F1 mice, 4,4'- oxydianiline increased adenomas of the harderian gland in male and female mice. 4,4'- Methylenedianiline (CAS: 101-77-9) in the drinking water increased neoplasms of the thyroid gland and liver in F344 rats and B6C3F1 mice.
给近交系F344大鼠喂食4,4'-亚甲基双（N,N-二甲基）苯胺[化学物质登录号：101-61-1；4,4'-亚甲基双（N,N-二甲基苯胺）]会增加两性甲状腺病变（增生、腺瘤和癌）的发生率，雌性大鼠尤为明显。饮食中的4,4'-二氨基二苯醚（化学物质登录号：101-80-4）会增加雄性和雌性F344大鼠甲状腺腺瘤和癌以及肝脏肿瘤结节和癌的发生率。除了增加雌性B6C3F1小鼠的甲状腺腺瘤以及雄性和雌性B6C3F1小鼠的肝细胞腺瘤或癌外，4,4'-二氨基二苯醚还增加了雄性和雌性小鼠的哈德氏腺腺瘤。饮用水中的4,4'-亚甲基二苯胺（化学物质登录号：101-77-9）会增加F344大鼠和B6C3F1小鼠甲状腺和肝脏的肿瘤发生率。
