van Berge-Henegouwen G P, Ferguson D R, Hofmann A F, De Pagter A G
Gut. 1978 May;19(5):345-9. doi: 10.1136/gut.19.5.345.
To determine whether a defect in uptake of organic anions is present in patients with benign recurrent cholestasis, the plasma disappearance of simultaneously injected indocyanine green and cholyglycine-1-14C was measured in eight patients with asymptomatic benign recurrent cholestasis, four with the familial type, as well as 22 healthy control subjects. Evans blue was also simultaneously injected to permit correction for variation in blood volume and speed of mixing. Uptake of indocyanine green was decreased in all three patients with nonfamilial benign recurrent cholestatsis, but normal or increased in the four patients uith the familial form of the disorder. By contrast, cholyglycine-1-14C uptake was abnormal in one patient with each type of the disorder. Thus, patients with nonfamilial benign recurrent cholestasis have a defect in indocyanine green uptake, and patients with benign recurrent cholestasis are heterogeneous with respect to organic anion uptake.
为了确定良性复发性胆汁淤积症患者是否存在有机阴离子摄取缺陷，我们对8例无症状良性复发性胆汁淤积症患者（其中4例为家族性）以及22名健康对照者，测定了同时注射的吲哚菁绿和甘氨胆酸-1-¹⁴C的血浆清除率。同时注射伊文思蓝以校正血容量和混合速度的变化。在所有3例非家族性良性复发性胆汁淤积症患者中，吲哚菁绿的摄取均降低，但在4例家族性疾病患者中正常或增加。相比之下，每种类型的疾病各有1例患者的甘氨胆酸-1-¹⁴C摄取异常。因此，非家族性良性复发性胆汁淤积症患者存在吲哚菁绿摄取缺陷，并且良性复发性胆汁淤积症患者在有机阴离子摄取方面具有异质性。
