Paleologo F P, Neafie R C, Connor D H
Am J Trop Med Hyg. 1984 May;33(3):395-402. doi: 10.4269/ajtmh.1984.33.395.
The World Health Organization's Collaborating Centre for the Histopathology of Filarial Diseases of Man contains specimens of lymph node from 13 patients infected by the filarial nematode Loa loa. Ten of these nodes have distinctive microscopic features characterized by distended sinuses that contain histiocytes and eosinophils and by atrophy of lymphoid follicles. Less striking features include fibrosis of capsule and trabeculae, dilated lymphatic vessels of capsule and medulla, and inflammatory cell infiltrates. We believe that these changes, although in themselves nonspecific, are characteristic of lymphadenitis caused by Loa loa. These 10 lymph nodes were removed from the inguinal region--one from each of 10 native Zairians . At the time of herniorrhaphy the nodes in eight patients were found to be enlarged and were removed for diagnosis. Seven of the 10 patients were infected with Dipetalonema perstans as well as Loa loa, and one of these seven had three filarial infections--L. loa, D. perstans and D. streptocerca . Lymph nodes from other patients infected by other filariae that were available for study at the AFIP did not have these histopathologic features.
世界卫生组织人类丝虫病组织病理学合作中心保存着13例感染罗阿丝虫的患者的淋巴结标本。其中10个淋巴结具有独特的微观特征，其特点是窦扩张，含有组织细胞和嗜酸性粒细胞，淋巴滤泡萎缩。不太明显的特征包括包膜和小梁纤维化、包膜和髓质的淋巴管扩张以及炎症细胞浸润。我们认为，这些变化虽然本身不具有特异性，但却是罗阿丝虫引起的淋巴结炎的特征。这10个淋巴结取自腹股沟区——10名扎伊尔本地人每人一个。在疝修补术时，8名患者的淋巴结被发现肿大并被切除以进行诊断。10名患者中有7名同时感染了常现棘唇线虫和罗阿丝虫，这7名患者中有1名感染了三种丝虫——罗阿丝虫、常现棘唇线虫和链尾唇棘线虫。在武装部队病理研究所可供研究的其他感染其他丝虫的患者的淋巴结没有这些组织病理学特征。
