α,α,β,β-四氘代-N,N-二甲基色胺在啮齿动物脑内的体内代谢
In vivo metabolism of alpha,alpha,beta,beta-tetradeutero-N, N-dimethyltryptamine in rodent brain.
作者信息
Barker S A, Beaton J M, Christian S T, Monti J A, Morris P E
出版信息
Biochem Pharmacol. 1984 May 1;33(9):1395-400. doi: 10.1016/0006-2952(84)90404-0.
The metabolism of alpha,alpha,beta,beta- tetradeutero -N,N -dimethyltryptamine ( D4DMT ) in rat brain in vivo as a function of time and dose was examined. Quantification of D4DMT and its respective deutero-metabolites was accomplished using gas chromatographic/mass spectrometric/selected ion monitoring/isotope dilution techniques. The results of this study indicate that D4DMT is metabolized to the corresponding deutero-N-methyltryptamine, tryptamine, 1,2,3,4-tetrahydro-beta-carboline, and 2-methyl-1, 2,3,4-tetrahydro-beta-carboline in rat brain. The subcellular distribution of D4DMT and the aforementioned metabolites is also reported.
研究了α,α,β,β-四氘代-N,N-二甲基色胺（D4DMT）在大鼠脑内的体内代谢随时间和剂量的变化情况。采用气相色谱/质谱/选择离子监测/同位素稀释技术对D4DMT及其相应的氘代代谢产物进行定量分析。本研究结果表明，D4DMT在大鼠脑内代谢为相应的氘代-N-甲基色胺、色胺、1,2,3,4-四氢-β-咔啉和2-甲基-1,2,3,4-四氢-β-咔啉。还报道了D4DMT及上述代谢产物的亚细胞分布情况。
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