Puri C P, Mac Kenzie L W, Garfield R E, Wiest W G
Biol Reprod. 1984 May;30(4):1027-38. doi: 10.1095/biolreprod30.4.1027.
Administration of indomethacin (10 mg/kg body weight, twice daily for 6 days) resulted in a significant (P less than 0.01) increase in the weight, and cross-sectional area of uteri of ovariectomized rats, whereas no such effects were observed following indomethacin administration to normal cycling rats. Prostaglandin F2 alpha (PGF2 alpha) content (ng/uterus) and concentration (ng/g wet weight) in the uterus of indomethacin-treated animals were reduced 40.4% and 60.8%. Simultaneous administration of either estradiol-17 beta (E2), progesterone testosterone with indomethacin to ovariectomized rats failed to reduce the uterine weight increase. On the contrary, concomitant administration of E2 (25 or 100 ng/day) and indomethacin resulted in uterine weight increases which were greater than those associated with indomethacin alone. Uterine E2 content was significantly higher in animals treated with indomethacin plus E2 as compared to those given estradiol alone. Uterine uptake of 2,4,6,7-[3H]E2 following i.v. administration was greater in animals pretreated with indomethacin (5 mg/kg, twice daily) for 3 days than in ovariectomized controls. These results suggest that prostaglandins may be involved in the regulation of uterine growth.
给予消炎痛（10毫克/千克体重，每日两次，共6天）可使去卵巢大鼠的子宫重量和横截面积显著增加（P小于0.01），而对正常发情周期的大鼠给予消炎痛后未观察到此类效果。消炎痛处理动物的子宫中前列腺素F2α（PGF2α）含量（纳克/子宫）和浓度（纳克/克湿重）分别降低了40.4%和60.8%。对去卵巢大鼠同时给予雌二醇-17β（E2）、孕酮或睾酮与消炎痛，未能减轻子宫重量的增加。相反，同时给予E2（25或100纳克/天）和消炎痛会导致子宫重量增加，且大于单独使用消炎痛时的增加幅度。与单独给予雌二醇的动物相比，消炎痛加E2处理的动物子宫中的E2含量显著更高。静脉注射2,4,6,7-[3H]E2后，用消炎痛（5毫克/千克，每日两次）预处理3天的动物子宫对其摄取量大于去卵巢对照组。这些结果表明，前列腺素可能参与子宫生长的调节。
