Graham N B, McNeill M E
Biomaterials. 1984 Jan;5(1):27-36. doi: 10.1016/0142-9612(84)90063-2.
Physical properties such as number average molecular weight Mn, specific hydrates and changing diffusion coefficient of crystalline/rubbery hydrogels based on poly(ethylene glycol) Mn 3 000-8 000 which affect the diffusion of drugs through the water swollen matrix and across the polymer boundary are discussed. The advantage of starting with a dry, drug-impregnated polymer to obtain the desirable zero order release rate while the hydrogel absorbs water is illustrated. Drugs have been classified into five groups showing different release profiles. The effects of design and loading on the release profile, are described including the first clinical results of morphine loaded hydrogel suppositories.
讨论了基于聚乙二醇（分子量Mn为3000 - 8000）的结晶/橡胶状水凝胶的物理性质，如数均分子量Mn、特定水合物以及变化的扩散系数，这些性质会影响药物在水溶胀基质中以及穿过聚合物边界的扩散。阐述了从干燥的、含药聚合物开始，在水凝胶吸水时获得理想零级释放速率的优势。药物已被分为五类，呈现出不同的释放曲线。描述了设计和载药量对释放曲线的影响，包括吗啡载药水凝胶栓剂的首批临床结果。
