Takagi T, Oguro M, Iwabuchi K
Gan To Kagaku Ryoho. 1984 Jul;11(7):1450-6.
Of 3 patients with adult ALL and 23 patients with NHL treated with intravenous administration of 10 mg/M2 of THP for 5 consecutive days, complete remission was observed in 3 patients and partial remission in 14. The antitumor spectrum of THP seemed to be similar to that of Adriamycin from evidence that THP was effective in patients with NHL of diffuse large and mixed cell type. Neither cardiotoxicity nor alopecia was noticed. Anorexia, nausea or vomiting was mild but granulocytopenia and thrombocytopenia were severe in the patients with ALL and leukemic type NHL. Further studies are required for determining cross resistance to other anthracyclines and an optimal dose schedule.
对3例成人急性淋巴细胞白血病（ALL）患者和23例非霍奇金淋巴瘤（NHL）患者连续5天静脉注射10mg/M²的吡柔比星进行治疗，3例患者完全缓解，14例部分缓解。从吡柔比星对弥漫大细胞型和混合细胞型NHL患者有效的证据来看，其抗肿瘤谱似乎与阿霉素相似。未观察到心脏毒性和脱发。厌食、恶心或呕吐较轻，但ALL患者和白血病型NHL患者的粒细胞减少和血小板减少严重。需要进一步研究以确定对其他蒽环类药物的交叉耐药性和最佳剂量方案。
