Wilson J S, Gossat D, Tait A, Rouse S, Juan X J, Pirola R C
Dig Dis Sci. 1984 Aug;29(8):727-30. doi: 10.1007/BF01312945.
To investigate the role of heredity in alcoholic pancreatitis, an HLA typing study has been performed. Patients with alcoholic pancreatitis exhibited an increased frequency of HLA Bw 39 when compared with the general population [13.6% vs 3.3%, P (corrected) less than 0.02; relative risk 4.7]. Alcoholics without pancreatitis did not differ from the general population with respect to HLA status, indicating that the increased incidence of HLA Bw 39 was related to alcoholic pancreatitis rather than to alcoholism itself. Thus, this study has provided evidence for a genetic predisposition to alcoholic pancreatitis.
为研究遗传因素在酒精性胰腺炎中的作用，我们开展了一项HLA分型研究。与普通人群相比，酒精性胰腺炎患者中HLA Bw 39的出现频率更高[13.6%对3.3%，校正P值小于0.02；相对风险为4.7]。无胰腺炎的酗酒者在HLA状态方面与普通人群无差异，这表明HLA Bw 39出现频率增加与酒精性胰腺炎有关，而非与酗酒本身相关。因此，本研究为酒精性胰腺炎的遗传易感性提供了证据。
