Wegman M R, Eisenberg A D, Curzon M E, Handelman S L
J Dent Res. 1984 Sep;63(9):1126-9. doi: 10.1177/00220345840630090601.
Fluoride (5 mg/l) consistently depressed the accumulation of intracellular iodophilic polysaccharides (IPS) in Streptococcus mutans strains BHT, FA-1, and GS-5 by over 90% and in Actinomyces viscosus strain RC-45 by over 50%. There was little further reduction in IPS content when fluoride was increased from 5 to 100 mg/l. Lithium (0 to 1 mg/l) neither enhanced nor inhibited IPS accumulation, nor did it modify the inhibitory effects of fluoride in three of the four strains tested. Strontium (0 to 100 mg/l) did not alter IPS accumulation in S. mutans GS-5 but decreased accumulation (less than 10%) in S. mutans FA-1 and BHT and significantly enhanced IPS accumulation in A. viscosus RC-45. Analysis of variance indicated no statistically significant interactions between fluoride and strontium, fluoride and lithium, or strontium and lithium.
氟化物（5毫克/升）持续抑制变形链球菌BHT、FA-1和GS-5菌株细胞内嗜碘多糖（IPS）的积累达90%以上，抑制粘性放线菌RC-45菌株细胞内嗜碘多糖的积累达50%以上。当氟化物浓度从5毫克/升增加到100毫克/升时，IPS含量几乎没有进一步降低。锂（0至1毫克/升）既不增强也不抑制IPS的积累，在测试的四种菌株中的三种中，它也不改变氟化物的抑制作用。锶（0至100毫克/升）不会改变变形链球菌GS-5中IPS的积累，但会降低变形链球菌FA-1和BHT中IPS的积累（低于10%），并显著增强粘性放线菌RC-45中IPS的积累。方差分析表明，氟化物与锶、氟化物与锂或锶与锂之间不存在统计学上的显著相互作用。
