Leslie C C, Musson R A, Henson P M
J Leukoc Biol. 1984 Aug;36(2):143-59. doi: 10.1002/jlb.36.2.143.
Macrophages, derived from human monocytes by in vitro culture, released a growth factor for rabbit lung fibroblasts. The release of growth factor was increased following stimulation with both soluble (lipopolysaccharide and phorbol myristate acetate) and particulate (opsonized zymosan) substances. Production of the growth factor activity was dependent on the length of time the monocytes were in culture, the presence of serum during the period of monocyte maturation, and macrophage protein synthesis. The inability of serum-deprived monocytes to produce growth factor could be reversed by adding back serum. Eicosatetraynoic acid and dexamethasone but not indomethacin inhibited the production of growth factor suggesting that arachidonic acid metabolites other than prostaglandins may regulate growth factor production.
通过体外培养从人单核细胞衍生而来的巨噬细胞释放出一种兔肺成纤维细胞生长因子。在用可溶性物质（脂多糖和佛波醇肉豆蔻酸酯乙酸酯）和颗粒物质（调理酵母聚糖）刺激后，生长因子的释放增加。生长因子活性的产生取决于单核细胞培养的时间长度、单核细胞成熟期间血清的存在以及巨噬细胞蛋白质合成。通过重新添加血清可以逆转血清剥夺的单核细胞产生生长因子的能力。二十碳四炔酸和地塞米松而非吲哚美辛抑制生长因子的产生，这表明除前列腺素外的花生四烯酸代谢物可能调节生长因子的产生。
