Woolf N
Bland-Sutton Institute of Pathology, University College, London, United Kingdom.
Drugs. 1988;36 Suppl 3:46-50. doi: 10.2165/00003495-198800363-00012.
Atherosclerosis can be defined in terms of the processes involved rather than in morphological terms, and there is evidence for possible roles of the macrophage in atherogenesis. The relevance of hyperlipidaemia to the morphogenesis of the atherosclerotic plaque is important, and this has been described in animal models including a strain of rabbit with a genetically determined hyperlipidaemia resembling familial combined hyperlipidaemia. Treatment of these animals with the HMG CoA reductase inhibitor lovastatin from the time of weaning results in a significant degree of inhibition of lesion formation.
动脉粥样硬化可以根据所涉及的过程来定义，而非从形态学角度定义，并且有证据表明巨噬细胞在动脉粥样硬化形成过程中可能发挥作用。高脂血症与动脉粥样硬化斑块形态发生的相关性很重要，这在动物模型中已有描述，包括一种具有遗传决定的高脂血症的兔种，其类似于家族性混合性高脂血症。从断奶时起用HMG CoA还原酶抑制剂洛伐他汀治疗这些动物，可显著抑制病变形成。
