Woods R L, Kildea P M, Gabriel S A, Freilich L S
Oral Surg Oral Med Oral Pathol. 1984 Jul;58(1):82-93. doi: 10.1016/0030-4220(84)90369-4.
Currently available endodontic filling materials for primary teeth demonstrate several inadequacies. Therefore, this study histologically evaluates Hydron (2-hydroxyethylmethacrylate) and zinc oxide and eugenol (ZOE) as primary tooth endodontic filling materials in dogs to compare the materials' biocompatibility and to determine whether they undergo resorption in a physiologic manner. Primary molars of six mongrel dogs, 2 to 3 months old, received one-step endodontic therapy. By random selection, two thirds of the molars were filled with either Hydron or ZOE and the remainder were used as unoperated controls. Block sections taken during physiologic root resorption were used to obtain serial hematoxylin and eosin sections of periapical regions. Hydron was phagocytosed by mononuclear macrophages in a physiologic manner and at a rate comparable to that of root tissues. In contrast, ZOE demonstrated delayed resorption and transitory inflammation. Neither material showed cytotoxicity. Hydron may therefore be a suitable endodontic material for human primary teeth.
目前可用的乳牙牙髓填充材料存在一些不足之处。因此，本研究通过组织学方法评估了Hydron（甲基丙烯酸2-羟乙酯）和氧化锌丁香酚（ZOE）作为犬乳牙牙髓填充材料的情况，以比较这两种材料的生物相容性，并确定它们是否以生理方式被吸收。对6只2至3个月大的杂种犬的乳磨牙进行了一步法牙髓治疗。通过随机选择，三分之二的磨牙用Hydron或ZOE填充，其余用作未处理的对照。在生理性牙根吸收期间获取的块状切片用于获得根尖周区域的连续苏木精和伊红切片。Hydron以生理方式被单核巨噬细胞吞噬，其速率与牙根组织相当。相比之下，ZOE显示出吸收延迟和短暂炎症。两种材料均未显示出细胞毒性。因此，Hydron可能是一种适合人类乳牙的牙髓材料。
