Christensson B, Hedström S A, Kronvall G
Scand J Infect Dis Suppl. 1983;41:140-3.
In comparison to healthy controls we have found that patients with endocarditis and septicaemia caused by Staphylococcus aureus show significantly higher antibody levels against either S. aureus peptidoglycan, crude staphylococcal antigen or alpha-toxin. The serological methods used in these studies were radio-immunoassays. These results have now been further evaluated concerning their clinical significance. The occurrence rate of S. aureus endocarditis and septicaemia at the clinic was 0.36% and 2.0%, respectively, during the study period. In spite of relatively high levels of test specificities, 93.8-96.9%, the predictive values for positive test results were low, 2.7-23.2%. Using the PG-assay, satisfactory predictive values of 100% together with a sensitivity of 95.2% could nevertheless be reached in the screening for S. aureus endocarditis, if the upper normal limit was raised.
与健康对照组相比，我们发现由金黄色葡萄球菌引起的心内膜炎和败血症患者针对金黄色葡萄球菌肽聚糖、粗制葡萄球菌抗原或α毒素的抗体水平显著更高。这些研究中使用的血清学方法是放射免疫测定法。现在已进一步评估了这些结果的临床意义。在研究期间，临床中金黄色葡萄球菌心内膜炎和败血症的发生率分别为0.36%和2.0%。尽管检测特异性相对较高，为93.8 - 96.9%，但阳性检测结果的预测值较低，为2.7 - 23.2%。然而，使用肽聚糖检测法，在筛查金黄色葡萄球菌心内膜炎时，如果提高正常上限，可达到100%的满意预测值以及95.2%的灵敏度。
