Henkind P, Gartner S
Trans Ophthalmol Soc U K (1962). 1983;103 ( Pt 4):444-7.
Absence of the choriocapillaris (CC) was observed histopathologically in human eyes with retinitis pigmentosa (RP). It was noted in areas where the overlying retinal pigment epithelium (RPE) was absent. Analysis of our material, as well as a review of the literature dealing with RP and related entities, as well as a number of other fundus disorders, suggested that the disappearance of the CC is secondary to REP degeneration. An experimental model using intravenous sodium iodate produced a similar sequence of events in the rabbit. We suggest that the RPE modulates structure and function of the CC. There is possibly a diffusable biochemical vascular modulation factor (VMF) which is required for normal CC fenestrae formation and maintenance, which is liberated by the normal RPE, and acts upon the vascular endothelium. Lack of VME causes the endothelium to lose its fenestrae and the vessel to occlude. This RPE-CC interaction is a further facet of the RPE which requires exploration in depth.
在患有视网膜色素变性（RP）的人眼中，组织病理学观察发现脉络膜毛细血管（CC）缺失。在视网膜色素上皮（RPE）缺失的区域可观察到这种情况。对我们的材料进行分析，以及对有关RP和相关病症以及其他一些眼底疾病的文献进行回顾后表明，CC的消失继发于RPE变性。使用静脉注射碘酸钠的实验模型在兔子身上产生了类似的一系列事件。我们认为RPE调节CC的结构和功能。可能存在一种可扩散的生化血管调节因子（VMF），它是正常CC窗孔形成和维持所必需的，由正常RPE释放，并作用于血管内皮。缺乏VME会导致内皮失去其窗孔，血管闭塞。这种RPE-CC相互作用是RPE需要深入探索的另一个方面。
