Byrd K E
Am J Orthod. 1984 Aug;86(2):146-61. doi: 10.1016/0002-9416(84)90306-3.
Unilateral electrolytic lesions were produced in the left trigeminal motor nucleus (TMN) of six guinea pigs at 49 days of age. Masticatory mandibular movement and EMG data were collected prior to lesioning and at 4 and 12 days postlesion. After the animals were killed 60 days postlesion, dissection and maceration revealed muscular atrophy and craniofacial asymmetries on the lesion side. Analyses of prelesion and postlesion mandibular movement and EMG data indicated significant (p less than 0.05; p less than 0.01) changes in chew cycle durations, dimensions, and EMG activity patterns. Shifts in EMG durations of working- and balancing-side muscles were strongly related to most of the observed skeletal asymmetries. Data indicated that muscular paresis and altered neuromuscular activity can effect skeletal changes in the mammalian craniofacial complex; total muscular paralysis is not a prerequisite for profound morphologic changes. Altered manifestation of masticatory central pattern generators within the central nervous system may also account for variations in craniofacial form and function.
对6只49日龄豚鼠的左侧三叉神经运动核（TMN）进行单侧电解损伤。在损伤前以及损伤后4天和12天收集咀嚼下颌运动和肌电图数据。在损伤后60天处死动物后，解剖和浸软显示损伤侧出现肌肉萎缩和颅面不对称。对损伤前后下颌运动和肌电图数据的分析表明，咀嚼周期持续时间、维度和肌电图活动模式有显著变化（p<0.05；p<0.01）。工作侧和平衡侧肌肉的肌电图持续时间变化与观察到的大多数骨骼不对称密切相关。数据表明，肌肉轻瘫和神经肌肉活动改变可影响哺乳动物颅面复合体的骨骼变化；完全肌肉麻痹并非深刻形态学变化的先决条件。中枢神经系统内咀嚼中枢模式发生器的改变表现也可能是颅面形态和功能变化的原因。
