Kaojarern S, Chennavasin P, Burdette A, Campbell W B, Brater D C
Clin Sci (Lond). 1984 Oct;67(4):413-20. doi: 10.1042/cs0670413.
Eight normal subjects underwent water loading alone and water loading plus 40 mg of frusemide IV, fluid intake ad libitum alone and fluid intake ad libitum plus frusemide, plus each of the preceding after pretreatment with indomethacin. After frusemide administration, increases in urinary sodium excretion paralleled increases in urinary volume, and urinary prostaglandin E2 (PGE2) excretion correlated closely with sodium excretion (y = 1.03x - 0.28; r = 0.940; P less than 0.0001). In the absence of the diuretic, urinary volume varied over a wide range with little change in sodium excretion. Again, urinary PGE2 excretion correlated with urinary sodium excretion (y = 0.12x + 0.05; r = 0.789; P less than 0.002). However, the correlation differed markedly from that observed in the studies with frusemide. Expressing urinary PGE2 excretion as a function of urinary volume for all of the studies resulted in a highly significant correlation (y = 10.7x - 0.70; r = 0.975; P less than 0.0001). Multiple and stepwise regression analyses assessing the correlation of urinary PGE2 excretion with urinary flow rate and with indices of function of various nephron segments indicate that the correlation with urinary PGE2 could be predominantly accounted for by urinary volume. We conclude that in the condition of this study in man, urinary PGE2 excretion is a correlate of urinary volume.
八名正常受试者分别接受单纯水负荷、水负荷加静脉注射40毫克速尿、随意饮水和随意饮水加服速尿，以及在吲哚美辛预处理后再进行上述每种处理。给予速尿后，尿钠排泄量的增加与尿量的增加平行，尿前列腺素E2（PGE2）排泄量与钠排泄量密切相关（y = 1.03x - 0.28；r = 0.940；P < 0.0001）。在没有利尿剂的情况下，尿量变化范围很大，而钠排泄量变化很小。同样，尿PGE2排泄量与尿钠排泄量相关（y = 0.12x + 0.05；r = 0.789；P < 0.002）。然而，这种相关性与使用速尿的研究中观察到的明显不同。将所有研究中的尿PGE2排泄量表示为尿量的函数，结果显示高度显著相关（y = 10.7x - 0.70；r = 0.975；P < 0.0001）。多元和逐步回归分析评估尿PGE2排泄量与尿流率以及不同肾单位节段功能指标之间的相关性，结果表明尿PGE2排泄量与尿量密切相关。我们得出结论，在本研究的人体条件下，尿PGE2排泄量与尿量相关。
