Irving C C, Murphy W M, Daniel D S
J Natl Cancer Inst. 1984 Sep;73(3):753-6.
The carcinogenicity of N-butyl-N-(3-carboxypropyl)-nitrosamine [CAS: 38252-74-3; 4-(N-butyl-N-nitrosamino)butyric acid] in male and female (C57BL/6 X DBA/2)F1 mice was determined. N-Butyl-N-(3-carboxypropyl)nitrosamine given in the drinking water at a concentration of 3 mM (0.056%) for 13 weeks induced only carcinoma of the urinary bladder in both sexes. At 22-28 weeks, the incidences of bladder cancer in the male and female mice were 100 and 88%, respectively. These bladder tumors were classified histologically according to the frequency (%) of tumor type: pure transitional cell carcinoma, 42%; mixed (transitional cell carcinoma with squamous or glandular differentiation, or both), 28%; squamous cell carcinoma, 27%; and carcinoma in situ, 3%. No significant sex differences were observed. In comparative studies, the incidence of bladder cancer was 100% for both sexes after administration of 3 mM (0.052%) N-butyl-N-(4-hydroxybutyl)nitrosamine [CAS: 3817-11-6; 4-(butylnitrosoamino)-1-butanol] in the drinking water. The frequency of pure transitional cell carcinoma was 47%, which was not significantly different from that observed for the carboxypropyl compound. The frequencies of other types of bladder carcinoma induced by N-butyl-N-(4-hydroxybutyl)nitrosamine were the following: mixed, 8%; squamous cell carcinoma, 42%; and carcinoma in situ, 3%.
测定了N-丁基-N-(3-羧丙基)亚硝胺[CAS: 38252-74-3；4-(N-丁基-N-亚硝氨基)丁酸]对雄性和雌性(C57BL/6×DBA/2)F1小鼠的致癌性。以3 mM(0.056%)的浓度在饮用水中给予N-丁基-N-(3-羧丙基)亚硝胺13周，仅在两性中诱发了膀胱癌。在22-28周时，雄性和雌性小鼠的膀胱癌发生率分别为100%和88%。这些膀胱肿瘤根据肿瘤类型的频率(%)进行组织学分类：纯移行细胞癌，42%；混合性(移行细胞癌伴有鳞状或腺性分化，或两者兼有)，28%；鳞状细胞癌，27%；原位癌，3%。未观察到明显的性别差异。在比较研究中，在饮用水中给予3 mM(0.052%)的N-丁基-N-(4-羟丁基)亚硝胺[CAS: 3817-11-6；4-(丁基亚硝氨基)-1-丁醇]后，两性的膀胱癌发生率均为100%。纯移行细胞癌的频率为47%，与羧丙基化合物观察到的频率无显著差异。N-丁基-N-(4-羟丁基)亚硝胺诱发的其他类型膀胱癌的频率如下：混合性，8%；鳞状细胞癌，42%；原位癌，3%。
