von Kries R, Ebell W, Jürgens H, Göbel U
Klin Padiatr. 1984 May-Jun;196(3):174-7.
Sequential coagulation tests were carried out in 13 children with acute nonlymphoblastic leukemia (ANLL) treated with the German cooperative protocols BFM 78 and 82. The test program included a PTT, Quick's Prothrombin time, Thrombin time, Fibrinogen (Clauss method and RID), coagulation factors II, V, VII, AT III, antiplasmin, plasminogen and FDP. Severe coagulation changes could be demonstrated in ANLL patients with FAB type M2 (myeloblastic leukemia with maturation) and FAB type M5 (monocytic leukemia). Usually they were found already at the time of diagnosis and improved during induction therapy. A variety of coagulation changes were observed, resembling classical DIC, typical hyperfibrinolysis or atypical proteolysis. It is allowed to question the concept of DIC as the typical coagulation disturbance in children with ANLL.
对13例接受德国BFM 78和82合作方案治疗的急性非淋巴细胞白血病（ANLL）患儿进行了连续凝血试验。测试项目包括部分凝血活酶时间（PTT）、奎克凝血酶原时间、凝血酶时间、纤维蛋白原（克劳斯法和火箭免疫电泳法）、凝血因子II、V、VII、抗凝血酶III（AT III）、抗纤溶酶、纤溶酶原和纤维蛋白降解产物（FDP）。在FAB分型为M2（伴有成熟的髓细胞白血病）和FAB分型为M5（单核细胞白血病）的ANLL患者中可证实有严重的凝血改变。通常在诊断时就已发现这些改变，并在诱导治疗期间有所改善。观察到了多种凝血改变，类似于经典的弥散性血管内凝血（DIC）、典型的高纤溶状态或非典型蛋白水解。对于DIC作为ANLL患儿典型凝血紊乱的概念提出质疑是合理的。
