Morrissey R B, Burkholder B D, Tarka S M
J Am Dent Assoc. 1984 Oct;109(4):589-91. doi: 10.14219/jada.archive.1984.0150.
The use of the animal model and the Konig-Hofer program-feeding machine is a valuable tool in the research effort to identify the factors contributing to dental caries. As this methodology provides uniform host, microflora, and frequency components, the food is the variable being evaluated. The relative cariogenicity of food is dependent on variations in the composition, texture, solubility, retentiveness, and ability to stimulate saliva flow. The results of these experiments indicated the equal importance of all food-related parameters on dental caries formation. If the composition of foods was solely responsible for dental caries formation, all three of the granola bars should have had similar relative cariogenicity values. This was not true. Granola bar no. 3, which was crispier in texture and less moist, had a third the relative cariogenicity value of granola bars nos. 1 and 2. As reported by other dental researchers, the production of dental caries is food related, but not simplistic in nature. Dental caries is the outcome of complicated interactions, all of which are equally important in the progress of this disease.
使用动物模型和柯尼希-霍费尔程序饲养机是确定导致龋齿的因素的研究工作中的一个有价值的工具。由于这种方法提供了统一的宿主、微生物群和频率成分,食物是被评估的变量。食物的相对致龋性取决于其成分、质地、溶解性、滞留性以及刺激唾液分泌的能力的变化。这些实验的结果表明,所有与食物相关的参数在龋齿形成中具有同等重要性。如果食物成分是导致龋齿形成的唯一原因,那么所有三种燕麦棒的相对致龋性值应该相似。但事实并非如此。质地更脆、湿度更小的3号燕麦棒的相对致龋性值仅为1号和2号燕麦棒的三分之一。正如其他牙科研究人员所报告的,龋齿的产生与食物有关,但本质上并不简单。龋齿是复杂相互作用的结果,所有这些相互作用在这种疾病的发展过程中都同样重要。