Mirkovitch V, Robinson J W, Mosimann F, Macarone-Palmieri R, Blanc D
Helv Chir Acta. 1978 May;45(1-2):125-7.
In dogs, the principal lesion in the ileal mucosa above a mechanical obstruction is the induction of a secretory state in which there is a net loss of water and electrolytes into the intestinal lumen. The role of stagnated bile as a possible agent provoking this secretion was explored by ligating the common bile duct and diverting the bile by means of an anastomosis between the gall bladder and the ileum distal to the obstruction. Seven days after creation of an obstruction with bile derivation, the functional and morphological changes in the obstructed loop were almost identical to those occurring in animals with obstructions without bile diversion. The secretory response above the obstruction continued unabated. These results suggest that the secretion in the obstructed intestine is not influeced by the presence of bile.
在犬类中，机械性肠梗阻上方回肠黏膜的主要病变是诱发一种分泌状态，即水分和电解质净流失至肠腔。通过结扎胆总管并借助胆囊与梗阻远端回肠之间的吻合术使胆汁改道，来探究停滞胆汁作为引发这种分泌的可能因素所起的作用。在造成梗阻并进行胆汁改道7天后，梗阻肠袢的功能和形态变化与未进行胆汁改道的梗阻动物几乎相同。梗阻上方的分泌反应持续未减。这些结果表明，梗阻肠道中的分泌不受胆汁存在的影响。
