Barrett A P
Oral Surg Oral Med Oral Pathol. 1984 Aug;58(2):148-51. doi: 10.1016/0030-4220(84)90128-2.
Thirty-three patients with acute leukemia or lymphoma received an ongoing topical treatment with an oral suspension of nystatin during prolonged periods of intensive chemotherapy and severe granulocytopenia. The preparation proved ineffective in eliminating colonized Candida species from the oropharynx in ten of eleven patients at the time of admission and was of questionable value in preventing later colonization in others. The difficulties surrounding the identification of systemic candidiasis, its significance in the immunosuppressed patient, and the role of topical antifungal prophylaxis are discussed.
33例急性白血病或淋巴瘤患者在接受长时间强化化疗及严重粒细胞减少期间，持续接受制霉菌素口服混悬液局部治疗。结果显示，该制剂对11例入院时口咽部已定植念珠菌的患者中的10例清除定植菌无效，对预防其他患者后续定植的价值也存在疑问。本文讨论了全身性念珠菌病的诊断难点、其在免疫抑制患者中的意义以及局部抗真菌预防的作用。
