Lozowski W, Hajdu S I
Acta Cytol. 1984 Sep-Oct;28(5):563-70.
This report is based on the review and study of primary gastrointestinal malignant lymphomas as seen in cytologic brushing and washing specimens. During a period of 12 years (1970 to 1981), a total of 2,675 patients with malignant lymphoma involving the gastrointestinal tract were seen at Memorial Sloan-Kettering Cancer Center. Of these patients, 73 were diagnosed as having primary malignant lymphoma of the gastrointestinal tract. A total of 49 preoperative cytologic specimens obtained from 29 patients with histologically confirmed primary gastrointestinal malignant lymphoma were examined and are the basis for this study. Twenty-four patients had gastric primaries; three tumors were in the colon and two were small intestinal lymphomas. Thirty-three cytologic specimens taken from 25 patients were considered diagnostic for malignant lymphoma. A positive cytologic brushing was the only diagnostic preoperative specimen for 9 of the 29 patients. Combined cytologic and biopsy specimens provided a diagnosis of malignant lymphoma for 16 patients. Cytologic washings did not add to the diagnostic accuracy. The 29 cases of malignant lymphoma reviewed here were histologically subclassified as 23 large-cell, poorly differentiated and six small-cell, well-differentiated lesions. The cytomorphologic features of malignant lymphoma as observed in gastrointestinal specimens are outlined, and differential diagnoses are discussed. Clinicopathologic implications of the cytologic findings are considered.
本报告基于对细胞学刷检和冲洗标本中所见原发性胃肠道恶性淋巴瘤的回顾与研究。在12年期间（1970年至1981年），纪念斯隆凯特琳癌症中心共收治了2675例累及胃肠道的恶性淋巴瘤患者。其中，73例被诊断为原发性胃肠道恶性淋巴瘤。本研究共检查了29例经组织学确诊的原发性胃肠道恶性淋巴瘤患者的49份术前细胞学标本。24例患者的原发部位在胃；3例肿瘤位于结肠，2例为小肠淋巴瘤。25例患者的33份细胞学标本被认为可诊断为恶性淋巴瘤。29例患者中有9例，阳性细胞学刷检是唯一的术前诊断标本。细胞学标本与活检标本相结合，为16例患者诊断出恶性淋巴瘤。细胞学冲洗并未提高诊断准确性。本文回顾的29例恶性淋巴瘤在组织学上分为23例大细胞、低分化和6例小细胞、高分化病变。概述了在胃肠道标本中观察到的恶性淋巴瘤的细胞形态学特征，并讨论了鉴别诊断。还考虑了细胞学检查结果的临床病理意义。
