Rönnberg L, Järvinen P A
Acta Obstet Gynecol Scand Suppl. 1984;123:69-72. doi: 10.3109/00016348409156986.
A total of 215 infertile patients with endometriosis verified at least laparoscopically were treated between 1977 and 1982 by conservative surgery alone (N = 90), or with danazol, 600 mg daily and most often for 6 months, either alone (N = 59) or postoperatively (N = 44), or by laparoscopic electrocautery of endometriotic foci (N = 18). The mean age and duration of infertility were about the same in all groups. The disease was mild in the electrocoagulated group, moderate in the groups treated either exclusively surgically or with danazol, and most severe among the patients who received danazol following surgery. The uncorrected pregnancy rate after conservative surgery was 43% and the mean interval until conception was 11.7 months. After 6 months' danazol treatment the uncorrected pregnancy rate was 56% and the mean interval until conception was significantly (p less than 0.02) shorter, 6.7 months. Conservative surgery followed by danazol treatment for 6 months resulted in fewer pregnancies (pregnancy rate 32%) but the mean interval until conception was about the same (6.9 months) as after danazol therapy alone. After laparoscopic electrocautery the pregnancy rate was only 17%. In view of these results, we recommend that for infertile patients with mild or moderate endometriosis the recommended treatment should be medical, e.g., danazol 600 mg daily for 6 months.
1977年至1982年间，对总共215例经腹腔镜至少确诊为子宫内膜异位症的不孕患者进行了治疗，其中仅接受保守手术治疗的有90例（N = 90）；接受达那唑治疗的有103例，每日600毫克，多数治疗6个月，其中单独使用达那唑治疗的有59例（N = 59），术后使用达那唑治疗的有44例（N = 44）；接受腹腔镜下子宫内膜异位病灶电灼治疗的有18例（N = 18）。所有组的平均年龄和不孕持续时间大致相同。电灼组疾病为轻度，单纯手术治疗组或达那唑治疗组疾病为中度，术后接受达那唑治疗的患者疾病最为严重。保守手术后未校正的妊娠率为43%，平均受孕间隔时间为11.7个月。达那唑治疗6个月后，未校正的妊娠率为56%，平均受孕间隔时间显著缩短（p<0.02），为6.7个月。保守手术后继以6个月达那唑治疗的妊娠率较低（妊娠率32%），但平均受孕间隔时间与单纯达那唑治疗后大致相同（6.9个月）。腹腔镜电灼术后妊娠率仅为17%。鉴于这些结果，我们建议对于轻度或中度子宫内膜异位症的不孕患者，推荐的治疗方法应为药物治疗，例如每日服用600毫克达那唑，持续6个月。
