Llorens-Cortes C, Schwartz J C
Eur J Pharmacol. 1984 Sep 17;104(3-4):369-74. doi: 10.1016/0014-2999(84)90415-1.
Thiorphan, an 'enkephalinase' inhibitor, and bestatin, an aminopeptidase inhibitor, decreased the turnover of noradrenaline and increased that of dopamine and serotonin in mouse brain regions. All effects were prevented by naloxone, indicating that when protected from the action of inactivating neuropeptidases endogenous enkephalins might affect monoaminergic neurons in the same way as exogenous opiates.
硫喷妥，一种“脑啡肽酶”抑制剂，以及贝司他汀，一种氨肽酶抑制剂，降低了小鼠脑区去甲肾上腺素的周转，并增加了多巴胺和5-羟色胺的周转。所有这些作用都被纳洛酮阻断，这表明当内源性脑啡肽免受失活神经肽酶作用的影响时，其对单胺能神经元的作用可能与外源性阿片类药物相同。
