Folkers K, Wolaniuk A, Vadhanavikit S
Proc Natl Acad Sci U S A. 1984 Nov;81(22):7076-8. doi: 10.1073/pnas.81.22.7076.
Differential enzymic analyses of the erythrocyte glutamic-oxaloacetic transaminase and the erythrocyte glutathione reductase of a patient with a 3-yr history of the carpal tunnel syndrome (CTS) revealed high deficiencies of both vitamin B-6 and riboflavin as based on approximately equal to 30% levels of the specific activities of these enzymes. Riboflavin for 5 months caused nearly complete disappearance of the CTS and caused no change in the specific activity of erythrocyte glutamic-oxaloacetic transaminase. Combined riboflavin and pyridoxine treatment increased (P less than 0.001) the specific activities of erythrocyte glutathione reductase and erythrocyte glutamic-oxaloacetic transaminase to normal levels with total disappearance of the CTS. Objectively, the strength of pinch of both hands increased (P less than 0.001) on treatment with riboflavin and further increased (P less than 0.001) on the combined treatment. For the first time, a significant riboflavin deficiency has been found to be related to CTS. Riboflavin therapy was effective biochemically, subjectively, and objectively, and riboflavin and pyridoxine were even more effective when concomitantly administered.
对一位患有3年腕管综合征（CTS）的患者的红细胞谷氨酸草酰乙酸转氨酶和红细胞谷胱甘肽还原酶进行差异酶分析发现，基于这些酶的比活性约为30%的水平，维生素B - 6和核黄素均严重缺乏。补充核黄素5个月使CTS几乎完全消失，且红细胞谷氨酸草酰乙酸转氨酶的比活性未发生变化。核黄素和吡哆醇联合治疗使红细胞谷胱甘肽还原酶和红细胞谷氨酸草酰乙酸转氨酶的比活性升高（P<0.001）至正常水平，CTS完全消失。客观上，双手捏力在核黄素治疗时增加（P<0.001），联合治疗时进一步增加（P<0.001）。首次发现明显的核黄素缺乏与CTS有关。核黄素治疗在生化、主观和客观方面均有效，核黄素和吡哆醇同时给药时效果更佳。
