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Promyelocytic blast crisis in chronic granulocytic leukemia with 15;17 translocation.

作者信息

Hogge D E, Misawa S, Schiffer C A, Testa J R

出版信息

Leuk Res. 1984;8(6):1019-23. doi: 10.1016/0145-2126(84)90056-0.

DOI:10.1016/0145-2126(84)90056-0
PMID:6595476
Abstract

A patient with Philadelphia chromosome Ph1-positive chronic granulocytic leukemia (CGL) developed an acute transformation associated with a hemorrhagic diathesis and bone marrow infiltration by hypergranular promyelocytes and blasts. Cytogenetic analysis of bone marrow metaphase cells at transformation showed a t(15;17) superimposed upon the Ph1-positive cell line. These findings suggest a critical relationship between the t(15;17) and arrest of myeloid leukemic cell differentiation at the promyelocyte stage.

摘要

相似文献

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Chromosome abnormalities in acute leukemia: its clinical implications and age of onset.
急性白血病中的染色体异常：其临床意义及发病年龄
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