药物毒性与激素功能障碍。
Drug toxicity and hormonal dysfunction.
作者信息
Eichelbaum M
出版信息
Arch Toxicol Suppl. 1984;7:39-47. doi: 10.1007/978-3-642-69132-4_4.
PMID:6596007
Abstract
Abnormal levels of hormones can exert profound changes in drug disposition and the number and affinity of receptors. In endocrine diseases a variety of organ functions change. These disease related changes in the function of organs involved with the distribution, metabolism and excretion of drugs can profoundly alter drug disposition. If not taken into account when devising dosage regimens drug toxicity can result.
摘要
激素水平异常会对药物的处置以及受体的数量和亲和力产生深远影响。在内分泌疾病中，多种器官功能会发生改变。这些与疾病相关的、涉及药物分布、代谢和排泄的器官功能变化，会深刻改变药物的处置。如果在制定给药方案时未加以考虑，可能会导致药物毒性。
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