Gershon M D, Bursztajn S
J Comp Neurol. 1978 Aug 1;180(3):467-88. doi: 10.1002/cne.901800305.
The possible presence of a blood-myenteric plexus barrier similar to the blood-nerve and blood-brain barriers was investigated. The myenteric plexus was found to be an enclosed tubular structure incompletely surrounded by a sheath of supporting cell processes. Capillaries do not enter the plexus. The capillaries which supply the myenteric layer differ in structure from capillaries of other layers of the gut and are non-fenestrated. Tracers, Evans blue labeled albumin or horseradish peroxidase, readily leak out of fenestrated capillaries, but do not readily escape from myenteric capillaries. These capillaries have impermeable junctions that prevent the passage of tracer between endothelial cells. A slow leakage of macromolecules is probably accounted for by transport through endothelial cells within plasmalemmal vesicles. A backup system of phagocytic cells removes this material and prevents the tracers leaking from the vasculature from reaching detectable concentrations in the extracellular space. Neither tracer was ever found in the myenteric plexus. Therefore, there is a blood-myenteric plexus barrier to macromolecules that resembles the blood-thymic barrier and may be functionally analogous to the blood-brain barrier.
研究了是否存在类似于血神经屏障和血脑屏障的血-肌间神经丛屏障。发现肌间神经丛是一个封闭的管状结构，不完全被支持细胞突起鞘所包围。毛细血管不进入神经丛。供应肌间层的毛细血管在结构上与肠道其他层的毛细血管不同，且无窗孔。示踪剂，伊文思蓝标记的白蛋白或辣根过氧化物酶，很容易从有窗孔的毛细血管中漏出，但不容易从肌间毛细血管中逸出。这些毛细血管具有阻止示踪剂在内皮细胞之间通过的紧密连接。大分子的缓慢渗漏可能是通过质膜小泡内的内皮细胞运输来解释的。吞噬细胞的后备系统清除这种物质，并防止示踪剂从血管系统渗漏到细胞外间隙中达到可检测的浓度。在肌间神经丛中从未发现过任何一种示踪剂。因此，存在一种对大分子的血-肌间神经丛屏障，它类似于血胸腺屏障，在功能上可能与血脑屏障相似。
