非抗肿瘤蒽环类类似物对多药耐药性的逆转作用
Reversal of multidrug resistance by non-antitumor anthracycline analogs.
作者信息
Inaba M, Nagashima K, Sakurai Y, Fukui M, Yanagi Y
出版信息
Gan. 1984 Dec;75(12):1049-52.
PMID:6597118
Abstract
It was found that three synthetic anthracycline analogs lacking not only antitumor activity but also calcium-antagonizing action possessed an activity to potentiate vincristine cytotoxicity against vincristine-resistant P388 leukemia. ID-8279, one of these analogs, significantly reversed resistance to vincristine and daunorubicin by increasing their intracellular accumulation.
摘要
研究发现，三种不仅缺乏抗肿瘤活性而且缺乏钙拮抗作用的合成蒽环类类似物具有增强长春新碱对长春新碱耐药的P388白血病细胞毒性的活性。其中一种类似物ID-8279通过增加长春新碱和柔红霉素在细胞内的蓄积，显著逆转了对这两种药物的耐药性。
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