Bergren D R, Myers D L
Prostaglandins Leukot Med. 1984 Nov;16(2):147-61. doi: 10.1016/0262-1746(84)90067-2.
Leukotriene C4 (LTC4) is a major component of slow-reacting substance of anaphylaxis (SRS-A) and is a potent bronchoconstrictor. In humans LTC4 results in bouts of coughing which suggests stimulation of pulmonary receptors involved in a reflex mechanism. Furthermore, atropine reduces the effect of both LTC4 and SRS-A. To test the hypothesis that LTC4 stimulates the rapidly-adapting or "irritant" receptor (RAR) of the airways, we administered LTC4 by both intravenous injection (10-1000 ng) and by aerosol delivery (1 microgram/ml) to the lungs of guinea pigs while recording arterial blood pressure, intratracheal pressure, and nerve activity from RARs. LTC4 (i.v.) concurrently increased both nerve activity and intratracheal pressure even at low doses in a dose-dependent manner. Therefore, a direct action of LTC4 (i.v.) upon the RAR is difficult to conclude. The separation of peak tracheal pressure and peak nerve activity was apparent with aerosol delivery of LTC4. The pattern of RAR activity during LTC4 aerosol challenge was unrelated to respiratory phase. FPL 55712 blocks the effects of SRS-A. We challenged the lung with 500 ng LTC4 intravenously before and after FPL 55712 injection (2.5 mg/kg). FPL 55712 blocked the increases of both tracheal pressure and RAR activity.
白三烯C4（LTC4）是过敏反应慢反应物质（SRS - A）的主要成分，是一种强效支气管收缩剂。在人类中，LTC4会引发咳嗽发作，这表明参与反射机制的肺受体受到了刺激。此外，阿托品可降低LTC4和SRS - A的作用。为了验证LTC4刺激气道快速适应性或“刺激性”受体（RAR）这一假设，我们在记录豚鼠动脉血压、气管内压力和RAR神经活动的同时，通过静脉注射（10 - 1000纳克）和气溶胶给药（1微克/毫升）两种方式将LTC4注入豚鼠肺部。即使在低剂量时，静脉注射LTC4也会以剂量依赖性方式同时增加神经活动和气管内压力。因此，很难得出静脉注射LTC4对RAR有直接作用的结论。通过气溶胶给药LTC4时，气管压力峰值和神经活动峰值明显分离。在LTC4气溶胶激发过程中，RAR活动模式与呼吸阶段无关。FPL 55712可阻断SRS - A的作用。在注射FPL 55712（2.5毫克/千克）前后，我们通过静脉注射500纳克LTC4对肺部进行激发。FPL 55712阻断了气管压力和RAR活动的增加。
