Rocca J M, Pieterse A S, Rowland R, Hecker R, Rich G E
Aust N Z J Med. 1984 Oct;14(5):606-10. doi: 10.1111/j.1445-5994.1984.tb05009.x.
We reviewed all rectal biopsies performed on patients with proven C. difficile infection between 1977 and 1982 (36 patients). All patients were symptomatic and all had received antibiotic treatment recently, the commonest antibiotic treatment being ampicillin or amoxycillin. There was poor correlation between the histological appearances and the severity of symptoms. A range of histological appearances was observed: normal (8%), congestion and edema (8%), nonspecific colitis (3%), infective colitis (28%) and pseudomembranous colitis (53%) (PMC). Most cases of PMC showed 'early' features, involving predominantly the surface epithelium, where attenuation and inflammation, intraepithelial microabscesses, and small eruptive lesions were seen. Recognition of these features, in the context of an acute infective-type colitis, may lead to early diagnosis of C. difficile colitis.
我们回顾了1977年至1982年间对确诊为艰难梭菌感染的患者进行的所有直肠活检（共36例患者）。所有患者均有症状，且近期均接受过抗生素治疗，最常用的抗生素治疗是氨苄西林或阿莫西林。组织学表现与症状严重程度之间的相关性较差。观察到一系列组织学表现：正常（8%）、充血和水肿（8%）、非特异性结肠炎（3%）、感染性结肠炎（28%）和假膜性结肠炎（53%）（PMC）。大多数PMC病例表现为“早期”特征，主要累及表面上皮，可见上皮变薄和炎症、上皮内微脓肿以及小的溃疡性病变。在急性感染性结肠炎的背景下认识到这些特征，可能有助于艰难梭菌结肠炎的早期诊断。
