提高难吸收药物的生物利用度。I. 中链甘油酯基质对大鼠头孢美唑钠直肠吸收的影响。
Improvement of bioavailability of poorly absorbed drugs. I. Effect of medium chain glyceride base on the rectal absorption of cefmetazole sodium in rats.
作者信息
Sekine M, Sasahara K, Kojima T, Hasegawa K, Okada R, Awazu S
出版信息
J Pharmacobiodyn. 1984 Nov;7(11):856-63. doi: 10.1248/bpb1978.7.856.
The effect of medium chain glyceride on the rectal absorption of cefmetazole sodium is investigated using an in situ experiment in rats. Each glyceride component of medium chain glyceride was separated using a high-performance liquid chromatographic method. The promoting effect of medium chain glyceride was found to be mainly due to glycerylmonocaprylate and dependent on the concentration of glycerylmonocaprylate. When cefmetazole sodium in medium chain glyceride solution was administered into the rectal lumen of rats, rapid absorption of the drug was observed leading to a residual amount of about 45% at 15 min after administration. The promoting effect of medium chain glyceride was found to be more effective in the rectum than in the small intestine.
采用大鼠原位实验研究中链甘油酯对头孢美唑钠直肠吸收的影响。利用高效液相色谱法分离中链甘油酯的各甘油酯成分。发现中链甘油酯的促进作用主要归因于单辛酸甘油酯，且依赖于单辛酸甘油酯的浓度。当中链甘油酯溶液中的头孢美唑钠给药至大鼠直肠腔时，观察到药物快速吸收，给药后15分钟残留量约为45%。发现中链甘油酯在直肠中的促进作用比在小肠中更有效。
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